Steroid Report

Researcher Jason Thomas, a graduate student in the doctoral program for synthetic organic chemistry at City University in New York, takes us inside the mind of a designer steroid chemist in an interview with Culturekiosque. Thomas describes a powerful tool that has the potential to create an infinite number of undetectable, designer anabolic steroids.

Once steroid designers specify the essential features and desired biological activity for steroid drug design, hundreds of novel designer steroids could be synthesized or simulated through Dynamic Combinatorial Chemistry (DCC) ["Designer Steroids: Speeding Evolution (and Filling Stadium Seats)" August 8]. 

Until now, human attempts to change testosterone’s anabolic, androgenic or estrogen-related properties have been relatively slow due to the fact that they have been addressed one at a time. A steroid designer imagines a certain compound, synthesizes it, and then tests it for effectiveness. This can take a matter of weeks or years. However, this process is about to undergo a drastic change. Dynamic Combinatorial Chemistry is a complicated process, so instead of explaining how it works I will simply provide the bottom line. Once steroid chemists have invested the necessary time into the chemical strategy for DCC, hundreds of novel steroid compounds can be synthesized and tested within a matter of minutes. The entire process is orchestrated by computers. The pharmaceutical sector has recently employed this process, and steroid manufactures will soon follow suit, if they haven’t already.

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The Hellenic Olympic Committee (HOC) president believes organized doping is behind the fifteen Greek athletes who have failed anti-doping tests before and during the 2008 Beijing Olympics. Former 400-meter hurdles champion Fani Halkia, swimmer Ioannis Drymonakos, 400-meter runner Dimitrios Regas, sprinter Tassos Gousis and eleven unidentified Greek weightlifters all tested positive for the same prohibited anabolic steroid – methyltrienolone (“HOC president: Greek sports face organized doping,” August 18). 

“There are 15 people, all with the same substance. This is the strangest thing, because it leads to the conclusion that there is an organized effort,” Minos Kyriakou told The Associated Press. The athletes — 11 weightlifters, three runners and a swimmer — all tested positive for methyltrienolone, a banned steroid. “There is an organized crime — because that is what this is called,” Kyriakou said. “Because it seems there is a lot of money hidden there, a lot of profit.”

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Eleven of the fourteen members of the Greek National Weightlifting Team have tested positve for the anabolic steroid methyltrienolone. Both samples A and B were positive for the steroid. This will likely result in the expulsion of the entire Greek Weightlifting Team from the 2008 Beijing Olympics.

Methyltrienolone is a very toxic oral anabolic steroid. However, reports by the Athens News that methytrienolone killed 200 bodybuilders in the 1960s are ludicrous. Researchers at the University of Bonn (Germany) blocked its commercial release in 1966 due to its high hepatotoxicity (liver toxicity). Professor Demetrios Kouretas (Department of Biochemistry and Biotechnology at the University of Thessaly) told Steroid Report he worked with the toxic steroid methyltrienolone as part of his postdoctoral thesis at the University of Harvard. Read the rest of this entry »

The jury verdict in cyclist Tammy Thomas’ perjury trial is factually and legally inconsistent. Most reports suggest the case was a “slam dunk” by the government with anywhere from strong to overwhelming evidence against Thomas.

The fact that Thomas was acquitted on two perjury charges is very significant. It may not be significant for Thomas, but it is significant in showing that the jury did not understand the law.

Basically, the jury determined that Tammy Thomas did NOT receive “banned or illegal performance-enhancing drugs” (i.e. legally-defined anabolic steroids) from Patrick Arnold. (Count 2)

They also determined that Tammy Thomas did NOT “ever get an anabolic steroid from anybody” (at least “up to the time of March 2002″). (Count 5)

But then they believed she was GUILTY of TAKING STEROIDS. (Count 4)

How did Tammy Thomas take steroids if she didn’t EVER get them from ANYBODY?! Read the rest of this entry »

Cyclist Tammy Thomas has been convicted on three counts of making false statements (perjury) and one count of obstruction of justice. She was acquitted of two counts of perjury (“Cyclist convicted of perjury in BALCO case,” April 4).

Under federal sentencing guidelines, Thomas faces a sentence that likely would range from probation to about two or three years in federal prison for the perjury convictions.

Thomas was specifically accused of lying to the grand jury about using steroids and obtaining performance enhancing drugs from Illinois chemist Patrick Arnold, a key Balco figure who pleaded guilty to manufacturing designer steroids and providing them to elite athletes through the now-defunct Peninsula laboratory.

Tammy Thomas already received a lifetime ban from competitive cycling for doping violations several years. This effectively ended her career as a cyclist. The conviction for perjury in the government’s case against Thomas may have effectively ended the pursuit of a second career as an attorney (“Tammy Thomas found guilty of perjury,” April 4).

“I already had one career taken away from me,” she yelled. “Look me in the eye. You can’t do it.”

Thomas then turned to a prosecutor and shouted, “Look me in the eye …. You like to destroy people’s lives.”

 The government has succeeded in its unstated goal of making an example of an athlete using steroids. Is this justice served?

The jury in cyclist Tammy Thomas’ doping perjury trial did not reach a verdict after the first day of deliberations (“Thomas jury deliberations to continue,” April 3).

Thomas, whose case is the first to go to trial in the five-and-a-half-year Balco investigation, was charged with making false statements to a grand jury in 2003 about substances she is suspected of receiving from Arnold. For the jury to convict Thomas, it must conclude that her statements were false and that they were material to the government’s investigation.

I am certain that Tammy Thomas is anxiously awaiting the verdict. Not only is her freedom in jeopardy but also a future career as an attorney. She has been silent about the case and has not spoken to the media; however, she has been very outspoken in her fashion statements outside the courtroom where she was photographed wearing a San Francisco Giants baseball cap, no doubt in support of other athletes who have been targeted for perjury by this federal investigation. Read the rest of this entry »

Fortunately (or unfortunately depending on your preference) we have not reached the level of absurdity where everything that may offer an unfair advantage is banned in sports competition. The latest culprit in offering an unfair advantage is not any type of designer anabolic steroid created by a rogue chemist in a secret underground lab. It is a new Speedo swimsuit (“The suit that’s turned the swim world on its head,” March 27).

The new swimsuit? Speedo’s LZR Racer.

That modest meet last month in Columbia, Mo., began an unprecedented — and controversial — six weeks that turned competitive swimming upside down: 14 world records set as of Wednesday, 13 in the LZR suit. Read the rest of this entry »

After corresponding with sources involved in the Tammy Thomas doping trial and reading reports from the trial, I am convinced that the likelihood of an acquittal is very high. The government’s case against cyclist Tammy Thomas for perjury is surprisingly weak. The government’s case is largely based on the assertion that Tammy Thomas ingested “anabolic steroids” and/or “controlled substances” and/or “banned substances” obtained from chemist Patrick Arnold and she lied about it.

The inconvenient fact is that tetrahydrogestrinone (THG) and norbolethone were NOT legally classified as “anabolic steroids” until the Anabolic Steroid Control Act of 2004 was passed; Norbolethone and THG were two of the 26 compounds added to the Controlled Substances Act with this legislation. Consequently, THG and norbolethone were NOT controlled substances until the passage of the legislation. Furthermore, THG and norbolethone were not on the WADA/IOC banned substances list at the time. Read the rest of this entry »

Several blogs have been discussing Neil Levin’s criticism of inaccuracies reported by CNN.  Levin strongly criticized CNN for “preposterous,” “erroneous,” and otherwise “false claims” that dietary supplements are “unregulated” and/or free of “government supervision.” His blog entry goes on to cite the many ways that dietary supplements are regulated by the government. The lengthy entry, with several quotes from regulatory agencies gives the impression that the dietary supplement industry is tightly regulated.

While CNN is technically inaccurate, it is closer to the truth than Levin’s advocacy would suggest. From a consumer standpoint, I feel it is safer to assume that dietary supplements are unregulated. Most regulations are actually “post-marketing” measures i.e. very little prevents a new supplement from being sold in the marketplace. Read the rest of this entry »

HBO Films is planning to make a movie about Barry Bonds and all the characters involved in the BALCO steroid scandal. They recently purchased the rights to the book “Game of Shadows” written by the investigative reporters Mark Fainaru-Wada and Lance Williams of the San Francisco Chronicle.

Hollywood is already promoting this as a “Barry Bonds” movie. I think everyone will be overloaded with stories about Bonds, if not already, by the time the movie is released on HBO. How many people will really want to see a movie about Barry Bonds?

Game of Shadows is well-written and interesting book that is about much more than Barry Bonds.  I hope that director Ron Shelton is able to breathe life into movie adaption with an engaging depiction of  the BALCO steroid scandal. I am hopeful as he has had some notable success with sports films: Read the rest of this entry »